The Raiders are fresh of the bye and will be looking to add another two points against the Panthers on Friday night.
Here are five things to be mindful of.
Who backs up?
The Panthers are one of the most affected teams when it comes to players backing up from State of Origin on Wednesday night in Melbourne.
The Panthers have Nathan Cleary, James Maloney, Tyrone Peachey and Reagan Campbell-Gillard featuring for New South Wales while Queensland's Josh Papalii is the only Raiders player set to feature in the match.
Nick Cotric is in the Blues camp and is unlikely to play which will see him line up on the left wing for the Raiders on Friday night.
With the clash on Friday being under 48 hours after the completion of Origin, it will be interesting to see whether the Panthers keep the 17 that was named on Tuesday with coach Anthony Griffin naming six reserves as cover.
Who is the team that the Raiders have faced the most since the club began in 1982? That's right, it's this weeks opposition.
The Raiders have gone head to head with the Panthers on 73 occasions with each side sharing the spoils accumulating 36 wins apiece and one drawn match back in 1996.
Win number 37 is on the table for one of these clubs to grasp on Friday night and take a slight advantage into the clash between the two clubs in Round 21.
Test against the best
The beginning of Round 14 sees the Panthers sitting in equal first position on the NRL Telstra Premiership ladder.
Just a few weeks ago the Raiders faced a table topping Dragons and put up a valiant effort which wasn't enough as they went down 25-18.
This week sees another opportunity to prove their credentials and attempt to close the gap between them and the top eight.
Wingers in for a field day
If history is anything to go by, Raiders wingers Jordan Rapana and Nick Cotric should be able to cross the stripe on Friday night.
Both wingers have four tries in their four most recent clashes with the Panthers which includes a double for each.
The Raiders will be hoping at least one of the two wingmen touch down for a four pointer on Friday.
Women's rugby league
The Gungahlin Bulls will face off with the Queanbeyan Kangaroos in the Katrina Fanning Shield following the completion of the Raiders vs Panthers NRL fixture.
The fixture gives the women a chance to showcase their skills on the big stage and a memory that will last a lifetime for some.
Stick around after the game and support the ladies with the match kicking off at 8:10pm.